Aliphatic Precursors of Pyrimidines in Neurospora
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چکیده
منابع مشابه
Proceedings: Precursors of cytochrome oxidase in cytochrome-oxidase deficient cells of Neurospora crassa.
Three different cell types of Neurospora crussa deficient in cytochrome oxidase were studied : the nuclear mutant cni-1, the cytoplasmic mutant mi-1 and copper-depleted wild-type cells. 1. The enzyme-deficient cells have retained a functioning mitochondrial protein synthesis. It accounted for 1216 % of the total protein synthesis of the cell. However, the analysis of mitochondrial translation p...
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On the basis of 102 assigned frequencies to in plane vibrations of pyrimidine, pyrimidine-2-d2, pyrimidine-2, 5-d2, pyrimidine-4,6-d2, pyrimidine-2,4,6-d3 and pyrimidine-d4, 35 valance force field constants including 14 principals and 21 interaction force constants are calculated. New assignments are suggested for n<su...
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The ability of Neurospora crassa FGSC 4335 in the biotransformation of hydrocortisone was investigated. The microorganism produced two major metabolites after incubation with the substrate for seven days. Each microbial product was purified chromatographically and identified on the basis of spectral data. The products were identified as 11?,17?,20?,21-tetrahydroxypregn-4-en-3-one (II) and 11?-h...
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As p a r t of a s tudy related to the effect of selected compounds on the incorporat ion of precursors into nucleic acid pyr imidines (8, 10), 5bromodeoxyur id ine ( B r U D R ) and a number of re lated nucleosides have been tested. I t was noted in a pre l iminary repor t t h a t the specific ac t iv i ty of D N A thymine was appreciably depressed when slices of h u m a n tumor t r ansp lan t ...
متن کاملPyrimidine studies. III. Effect of several compounds with antitumor activity on utilization of precursors for synthesis of nucleic acid pyrimidines.
Addition of amethopterin to an incubation medium containing slices of the human tumor transplants H.S. #1 and II.Ep. #3 decreased selectively the utilization of orotie acid-C 1~ for the synthesis of DNA thymine. A substantially larger depression of the specific activity of DNA thymine was observed upon addition of both amethopterin and 5-bromouridine to the incubation medium than upon addition ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69654-1